Postdoctoral Research Associate
shirig at uw.edu
A molecular biologist by training, in my PhD I developed tools, and studied responses to environmental stresses in a well-established model diatom in the lab. Now I am studying the molecular mechanisms underlying diatoms acclimation and stress response from model species to ecosystems, coupling laboratory studies with metatranscriptomes and novel isolates from the Pacific Ocean.
Education
- PhD, Life Science, Weizmann Institute of Science, Israel, 2019
- MSc, Life Science, Weizmann Institute of Science, Israel, 2013
- BSc, Molecular Biochemistry, The Technion – Israel Institute of Technology, Israel, 2010
Publications
- Graff van Creveld S, Coesel S, Schatz M, Armbrust E (under review) New eukaryotic phytoplankton isolates from the oligotrophic tropical Pacific Ocean. J. Phycol.
- Graff van Creveld S, Coesel S, Blaskowski S, Groussman R, Schatz M, Armbrust V (2023) Divergent functions of two clades of flavodoxin in diatoms mitigate oxidative stress and iron limitation. eLife. https://doi.org/10.7554/eLife.84392
- Bartolek Z, Graff van Creveld S, Coesel S, Cain K, Schatz M, Morales R, Armbrust V (2022) Flavobacterial exudates disrupt cell cycle progression and metabolism of the diatom Thalassiosira pseudonana. ISME J. doi: https://doi.org/10.1038/s41396-022-01313-9
- Graff van Creveld S, Mizrachi A, Vardi A (2022) “An ocean of signals: intracellular and extracellular signaling in diatom” in: The Molecular Life of Diatoms, Eds Falciatore A and Mock T, Springer Nature (London, England)
- Graff van Creveld S, Ben-dor S, Mizrachi A, Alcolombri U, Hopes A, Mock T, Rosenwasser S, Vardi A (2021) Biochemical Characterization of a Novel Redox-Regulated Metacaspase in a Marine Diatom. Front. Microbiol. doi: https://doi.org/10.3389/fmicb.2021.688199
- Mizrachi A, Graff van Creveld S, Shapiro OH, Rosenwasser S, Vardi A (2019) Light-dependent single-cell heterogeneity in the chloroplast redox state regulates cell fate in a marine diatom. eLife 8:e47732
- Stock F, Syrpas M, Graff van Creveld S, Backx S, Blommaert L, Dow L, Stock W, Ruysbergh E, Lepetit B, Bailleul B, et al (2019) N-acyl homoserine lactone derived tetramic acids impair photosynthesis in Phaeodactylum tricornutum. ACS Chem Biol acschembio.8b01101
- Volpert A, Graff van Creveld S, Rosenwasser S, Vardi A (2018) Diurnal fluctuations in chloroplast GSH redox state regulate susceptibility to oxidative stress and cell fate in a bloom-forming diatom. J Phycol 54: 329–341
- Rosenwasser S, Ziv C, Graff van Creveld S, Vardi A (2016) Virocell Metabolism: Metabolic Innovations During Host–Virus Interactions in the Ocean. Trends Microbiol 24: 821–832
- Graff van Creveld S, Rosenwasser S, Levin Y, Vardi A (2016) Chronic iron limitation confers transient resistance to oxidative stress in marine diatoms. Plant Physiol 172: 968–979
- Graff van Creveld S, Rosenwasser S, Schatz D, Koren I, Vardi A (2015) Early perturbation in mitochondria redox homeostasis in response to environmental stress predicts cell fate in diatoms. ISME J 9: 385–395
- Rosenwasser S, Graff van Creveld S, Schatz D, Malitsky S, Tzfadia O, Aharoni A, Levin Y, Gabashvili A, Feldmesser E, Vardi A (2014) Mapping the diatom redox-sensitive proteome provides insight into response to nitrogen stress in the marine environment. Proc Natl Acad Sci 111: 2740–5
Cruise participation
- 22 Jan - 18 Feb 2023, San Diego, CA - Honolulu, HI. R/V Thompson TN412, Chief Scientist: E. Virginia Armbrust, University of Washington
- 11 Nov - 15 Dec 2021, Seattle, WA - San Diego, CA - Honolulu, HI. R/V Thompson TN396 TN397, Chief Scientist: E. Virginia Armbrust, University of Washington
- 21 Apr - 4 May 2012, Woods Hole, MA - Bermuda, R/V Knorr KN203-1, Chief Scientist: Ben Van Mooy, Woods Hole Oceanographic Institute
Addgene plasmids
Plasmids deposited in Addgene, for gene editing in Phaeodactylum triconutum