Shiri Graff van Creveld

Shiri Graff van Creveld

Postdoctoral Research Associate

shirig at uw.edu

A molecular biologist by training, in my PhD I studied stress responses in a well-established model diatom in the lab. Now I am studying the molecular mechanisms underlying diatoms acclimation and stress response from model species to ecosystems, coupling laboratory studies with the field.

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Education

  • PhD, Life Science, Weizmann Institute of Science, Israel, 2018
  • MSc, Life Science, Weizmann Institute of Science, Israel, 2012
  • BSc, Molecular Biochemistry, The Technion – Israel Institute of Technology, Israel, 2009

Publications

  • Bartolek Z, Graff van Creveld S, Coesel S, Cain K, Schatz M, Morales R, Armbrust V (Accepted, 2022) Flavobacterial exudates disrupt cell cycle progression and metabolism of the diatom Thalassiosira pseudonana. ISME J
  • Graff van Creveld S, Mizrachi A, Vardi A (2022) “An ocean of signals: intracellular and extracellular signaling in diatom” in: The Molecular Life of Diatoms, Eds Falciatore A and Mock T, Springer Nature (London, England)
  • Graff van Creveld S, Ben-dor S, Mizrachi A, Alcolombri U, Hopes A, Mock T, Rosenwasser S, Vardi A (2021) Biochemical Characterization of a Novel Redox-Regulated Metacaspase in a Marine Diatom. Front. Microbiol. doi: https://doi.org/10.3389/fmicb.2021.688199
  • Mizrachi A, Graff van Creveld S, Shapiro OH, Rosenwasser S, Vardi A (2019) Light-dependent single-cell heterogeneity in the chloroplast redox state regulates cell fate in a marine diatom. Elife 8:e47732
  • Stock F, Syrpas M, Graff van Creveld S, Backx S, Blommaert L, Dow L, Stock W, Ruysbergh E, Lepetit B, Bailleul B, et al (2019) N-acyl homoserine lactone derived tetramic acids impair photosynthesis in Phaeodactylum tricornutum. ACS Chem Biol acschembio.8b01101
  • Volpert A, Graff van Creveld S, Rosenwasser S, Vardi A (2018) Diurnal fluctuations in chloroplast GSH redox state regulate susceptibility to oxidative stress and cell fate in a bloom-forming diatom. J Phycol 54: 329–341
  • Rosenwasser S, Ziv C, Graff van Creveld S, Vardi A (2016) Virocell Metabolism: Metabolic Innovations During Host–Virus Interactions in the Ocean. Trends Microbiol 24: 821–832
  • Graff van Creveld S, Rosenwasser S, Levin Y, Vardi A (2016) Chronic iron limitation confers transient resistance to oxidative stress in marine diatoms. Plant Physiol 172: 968–979
  • Graff van Creveld S, Rosenwasser S, Schatz D, Koren I, Vardi A (2015) Early perturbation in mitochondria redox homeostasis in response to environmental stress predicts cell fate in diatoms. ISME J 9: 385–395
  • Rosenwasser S, Graff van Creveld S, Schatz D, Malitsky S, Tzfadia O, Aharoni A, Levin Y, Gabashvili A, Feldmesser E, Vardi A (2014) Mapping the diatom redox-sensitive proteome provides insight into response to nitrogen stress in the marine environment. Proc Natl Acad Sci 111: 2740–5

Cruise participation

  • 11 Nov - 15 Dec 2021, Seattle, WA - San Diego, CA - Honolulu, HI. R/V Thompson TN396 TN397, Chief Scientist: E. Virginia Armbrust, University of Washington
  • 21 Apr - 4 May 2012, Woods Hole, MA - Bermuda, R/V Knorr KN203-1, Chief Scientist: Ben Van Mooy, Woods Hole Oceanographic Institute

Addgene plasmids

Plasmids deposited in Addgene, for gene editing in Phaeodactylum triconutum